FGF21 drives a shift in adipokine tone to restore metabolic health
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چکیده
منابع مشابه
FGF21 drives a shift in adipokine tone to restore metabolic health
Fibroblast growth factor 21 (FGF21) is a key metabolic regulator with significant potential to treat metabolic disease. Rather than traditional glucose or lipid centric therapies, FGF21 instead functions via expansive remodeling of whole body energy balance [1]. While FGF21’s ability to ameliorate disease burden is well established in species ranging from mice to men, the mechanism(s) by which ...
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The epidemic of obesity is a major health problem that leads to medical and socioeconomic burdens on society. Although body mass index (BMI) has been the most commonly used measure to determine the degree of obesity, it does not necessarily reflect the degree of adiposity. Recent observations show that some subpopulations exhibit unexpected metabolic profiles that deviate from the typical dose-...
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OBJECTIVE To investigate renal elimination of the adipokine fibroblast growth factor 21 (FGF21) by determining circulating FGF21 levels in patients on chronic hemodialysis (CD) as compared with control subjects with a glomerular filtration rate (GFR) >50 ml/min. RESEARCH DESIGN AND METHODS FGF21 was determined by enzyme-linked immunosorbent assay in control (n = 60) and CD (n = 60) patients a...
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OBJECTIVE Fructose consumption has been implicated in the development of obesity and insulin resistance. Emerging evidence shows that fibroblast growth factor 21 (FGF21) has beneficial effects on glucose, lipid, and energy metabolism and may also mediate an adaptive response to fructose ingestion. Fructose acutely stimulates circulating FGF21 consistent with a hormonal response. We aimed to eva...
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ژورنال
عنوان ژورنال: Aging
سال: 2013
ISSN: 1945-4589
DOI: 10.18632/aging.100565